Casein kinase 1 inhibitor avoids TDP-43 pathology propagation in a patient-derived cellular model of amyotrophic lateral sclerosis

Casein kinase 1 inhibitor avoids TDP-43 pathology propagation in a patient-derived cellular model of amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis is a fatal neurodegenerative disease without a cure to reverse its progression. Its main hallmark is the nuclear protein TDP-43, which undergoes different post-translational modifications leading to a loss of function in the nucleus and an increase in toxicity in the cy...

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Bibliographic Details
Main Authors: Eva P. Cuevas, Loreto Martinez-Gonzalez, Clara Gordillo, Carlota Tosat-Bitrián, Carmen Pérez de la Lastra, Amets Sáenz, Carmen Gil, Valle Palomo, Ángeles Martin-Requero, Ana Martinez
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Neurobiology of Disease
Subjects:
Amyotrophic lateral sclerosis
TDP-43
CK-1 inhibitor
Benzothiazole IGS2.17
Cell-to-cell disease propagation, extracellular vesicles
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996124000299

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http://www.sciencedirect.com/science/article/pii/S0969996124000299

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