Activated Endolysosomal Cation Channel TRPML1 Facilitates Maturation of α-Synuclein-Containing Autophagosomes

Activated Endolysosomal Cation Channel TRPML1 Facilitates Maturation of α-Synuclein-Containing Autophagosomes

Background: Protein aggregates are degraded via the autophagy-lysosome pathway and alterations in the lysosomal system leading to the accumulation of pathogenic proteins, including aggregates of α-synuclein in Parkinson’s disease (PD). The importance of the endolysosomal transient receptor potential...

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Bibliographic Details
Main Authors: Maike R. Pollmanns, Judith Beer, Ines Rosignol, Natalia Rodriguez-Muela, Björn H. Falkenburger, Elisabeth Dinter
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Parkinson’s disease
synuclein
TRPML1
mucolipin-1
ML-SA1
autophagy
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2022.861202/full

Internet

https://www.frontiersin.org/articles/10.3389/fncel.2022.861202/full

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