The role of angiotensin receptor blocker (losartan) on decreasing fibrotic process of corpora cavernosa in priapism model of wistar rats [version 3; peer review: 1 approved, 2 approved with reservations]

The role of angiotensin receptor blocker (losartan) on decreasing fibrotic process of corpora cavernosa in priapism model of wistar rats [version 3; peer review: 1 approved, 2 approved with reservations]

Background Priapism induces regulation of Transforming Growth Factor-β1 (TGF-β1) expression and collagen-type-1 deposition. This will replace the normal corpora cavernosa with fibrotic tissue which eventually resulted in erectile dysfunction. It is also known that the fibrosis process of corpora cav...

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Bibliographic Details
Main Authors: Rangga Adhazi Ksatriapraja, Dicky Stefanus, Rulianov Rulianov, Safendra Siregar
Format: Article
Language:English
Published: F1000 Research Ltd 2024-02-01
Series:F1000Research
Subjects:
Angiotensin II receptor blocker
Losartan
Collagen
Transforming Growth Factor
Priapism
collagen type I
eng
Online Access:https://f1000research.com/articles/11-831/v3

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