Ras-induced changes in H3K27me3 occur after those in transcriptional activity.
Oncogenic signaling pathways regulate gene expression in part through epigenetic modification of chromatin including DNA methylation and histone modification. Trimethylation of histone H3 at lysine-27 (H3K27), which correlates with transcriptional repression, is regulated by an oncogenic form of the...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2013-08-01
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| Series: | PLoS Genetics |
| Online Access: | http://europepmc.org/articles/PMC3757056?pdf=render |