Tolerogenic IDO1<sup>+</sup>CD83<sup>−</sup> Langerhans Cells in Sentinel Lymph Nodes of Patients with Melanoma

Tolerogenic IDO1<sup>+</sup>CD83<sup>−</sup> Langerhans Cells in Sentinel Lymph Nodes of Patients with Melanoma

Langerhans cells (LCs) are crucial regulators of anti-cancer immune responses. Cancer, however, can alter DCs functions leading to tolerance. The enzyme indoleamine 2,3-dioxygenase (IDO1) plays a crucial role in this process. In sentinel lymph nodes (SLNs) of patients with melanoma, LCs show phenoty...

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Bibliographic Details
Main Authors: Gianni Gerlini, Paola Di Gennaro, Nicola Pimpinelli, Serena Sestini, Lorenzo Borgognoni
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:International Journal of Molecular Sciences
Subjects:
melanoma
Langerhans cells
indoleamine 2
3-dioxygenase
sentinel lymph node
tolerance
Online Access:https://www.mdpi.com/1422-0067/23/7/3441

Internet

https://www.mdpi.com/1422-0067/23/7/3441

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