A modeling‐based proposal for safe and efficacious reintroduction of bedaquiline after dose interruption: A population pharmacokinetics study
Abstract Bedaquiline (BDQ) is recommended for treatment of multidrug‐resistant tuberculosis (MDR‐TB) for the majority of patients. Given its long terminal half‐life and safety concerns, such as QTc‐prolongation, re‐introducing BDQ after multiple dose interruption is not intuitive and there are curre...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-05-01
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| Series: | CPT: Pharmacometrics & Systems Pharmacology |
| Online Access: | https://doi.org/10.1002/psp4.12768 |