Biophysical characterization of light-gated ion channels using planar automated patch clamp

Channelrhodopsins (ChRs) are proteins that guide phototaxis in protists and exhibit light-gated channel conductance when their genes are heterologously expressed in mammalian cells. ChRs are widely used as molecular tools to control neurons and cardiomyocytes with light (optogenetics). Cation- and a...

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Bibliographic Details
Main Authors: Elena G. Govorunova, Oleg A. Sineshchekov, Leonid S. Brown, John L. Spudich
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2022.976910/full