PGC1β regulates multiple myeloma tumor growth through LDHA‐mediated glycolytic metabolism

PGC1β regulates multiple myeloma tumor growth through LDHA‐mediated glycolytic metabolism

Multiple myeloma (MM) is an incurable hematologic malignancy due to inevitable relapse and chemoresistance development. Our preliminary data show that MM cells express high levels of PGC1β and LDHA. In this study, we investigated the mechanism behind PGC1β‐mediated LDHA expression and its contributi...

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Bibliographic Details
Main Authors: Hongyu Zhang, Ling Li, Qi Chen, Min Li, Jia Feng, Ying Sun, Rong Zhao, Yin Zhu, Yang Lv, Zhigang Zhu, Xiaodong Huang, Weiguo Xie, Wei Xiang, Paul Yao
Format: Article
Language:English
Published: Wiley 2018-09-01
Series:Molecular Oncology
Subjects:
glycolysis
lactate dehydrogenase
LDHA
mitochondria
multiple myeloma
PGC1β
Online Access:https://doi.org/10.1002/1878-0261.12363

Internet

https://doi.org/10.1002/1878-0261.12363

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