Involvement of Nrf2-HO-1/JNK-Erk Signaling Pathways in Aconitine-Induced Developmental Toxicity, Oxidative Stress, and ROS-Mitochondrial Apoptosis in Zebrafish Embryos

Involvement of Nrf2-HO-1/JNK-Erk Signaling Pathways in Aconitine-Induced Developmental Toxicity, Oxidative Stress, and ROS-Mitochondrial Apoptosis in Zebrafish Embryos

Aconitine (AC), one of the bioactive diterpenoid alkaloids extracted from Aconitum plants, is widely used in traditional herbal medicine to treat various diseases. Emerging evidence indicates that AC has attracted great interest for its wide cardiotoxicity and neurotoxicity. However, the toxic effec...

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Bibliographic Details
Main Authors: Qing Xia, Shuo Gao, Samuel Rajendran Rapael Gnanamuthu, Kaiyan Zhuang, Zhenzhen Song, Yun Zhang, Xue Wang, Pengfei Tu, Jianheng Li, Kechun Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Pharmacology
Subjects:
aconitine
developmental toxicity
oxidative stress
mitochondrial apoptosis
zebrafish
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.642480/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.642480/full

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