A high-fat and fructose diet in dogs mirrors insulin resistance and β-cell dysfunction characteristic of impaired glucose tolerance in humans.

A high-fat and fructose diet in dogs mirrors insulin resistance and β-cell dysfunction characteristic of impaired glucose tolerance in humans.

This study examined the impact of a hypercaloric high-fat high-fructose diet (HFFD) in dogs as a potential model for human impaired glucose tolerance (IGT) and type 2 diabetes mellitus (T2DM). The HFFD not only led to weight gain but also triggered metabolic alterations akin to the precursors of hum...

Full description

Bibliographic Details
Main Authors: Justin M Gregory, Guillaume Kraft, Chiara Dalla Man, James C Slaughter, Melanie F Scott, Jon R Hastings, Dale S Edgerton, Mary C Moore, Alan D Cherrington
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0296400

Internet

https://doi.org/10.1371/journal.pone.0296400

Similar Items