Difluorocarbene enables to access 2-fluoroindoles from ortho-vinylanilines
2-Fluoroindoles are an important structural scaffold in many bioactive or therapeutic agents, but efficient constructions of 2-fluoroindole derivatives are very sparce. Here the authors report an efficient and general strategy for the construction of 2-fluoroindoles in which a wide variety of 2-fluo...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-25313-z |
| _version_ | 1818422077266329600 |
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| author | Jianke Su Xinyuan Hu Hua Huang Yu Guo Qiuling Song |
| author_facet | Jianke Su Xinyuan Hu Hua Huang Yu Guo Qiuling Song |
| author_sort | Jianke Su |
| collection | DOAJ |
| description | 2-Fluoroindoles are an important structural scaffold in many bioactive or therapeutic agents, but efficient constructions of 2-fluoroindole derivatives are very sparce. Here the authors report an efficient and general strategy for the construction of 2-fluoroindoles in which a wide variety of 2-fluoroindoles were accessed with high efficiency and chemoselectivity. |
| first_indexed | 2024-12-14T13:20:31Z |
| format | Article |
| id | doaj.art-b4f06b0e23554d8d98d302d48e9c4054 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T13:20:31Z |
| publishDate | 2021-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-b4f06b0e23554d8d98d302d48e9c40542022-12-21T22:59:56ZengNature PortfolioNature Communications2041-17232021-08-0112111010.1038/s41467-021-25313-zDifluorocarbene enables to access 2-fluoroindoles from ortho-vinylanilinesJianke Su0Xinyuan Hu1Hua Huang2Yu Guo3Qiuling Song4Institute of Next Generation Matter Transformation, College of Material Sciences Engineering, Huaqiao UniversityInstitute of Next Generation Matter Transformation, College of Material Sciences Engineering, Huaqiao UniversityInstitute of Next Generation Matter Transformation, College of Material Sciences Engineering, Huaqiao UniversityInstitute of Next Generation Matter Transformation, College of Material Sciences Engineering, Huaqiao UniversityInstitute of Next Generation Matter Transformation, College of Material Sciences Engineering, Huaqiao University2-Fluoroindoles are an important structural scaffold in many bioactive or therapeutic agents, but efficient constructions of 2-fluoroindole derivatives are very sparce. Here the authors report an efficient and general strategy for the construction of 2-fluoroindoles in which a wide variety of 2-fluoroindoles were accessed with high efficiency and chemoselectivity.https://doi.org/10.1038/s41467-021-25313-z |
| spellingShingle | Jianke Su Xinyuan Hu Hua Huang Yu Guo Qiuling Song Difluorocarbene enables to access 2-fluoroindoles from ortho-vinylanilines Nature Communications |
| title | Difluorocarbene enables to access 2-fluoroindoles from ortho-vinylanilines |
| title_full | Difluorocarbene enables to access 2-fluoroindoles from ortho-vinylanilines |
| title_fullStr | Difluorocarbene enables to access 2-fluoroindoles from ortho-vinylanilines |
| title_full_unstemmed | Difluorocarbene enables to access 2-fluoroindoles from ortho-vinylanilines |
| title_short | Difluorocarbene enables to access 2-fluoroindoles from ortho-vinylanilines |
| title_sort | difluorocarbene enables to access 2 fluoroindoles from ortho vinylanilines |
| url | https://doi.org/10.1038/s41467-021-25313-z |
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