Inhibition of Nur77 expression and translocation by compound B6 reduces ER stress and alleviates cigarette smoke-induced inflammation and injury in bronchial epithelial cells

Inhibition of Nur77 expression and translocation by compound B6 reduces ER stress and alleviates cigarette smoke-induced inflammation and injury in bronchial epithelial cells

Chronic obstructive pulmonary disease (COPD) is a leading cause of death worldwide with inflammation and injury in airway epithelial cells. However, few treatment options effectively reduce severity. We previously found that Nur77 is involved in lipopolysaccharide-induced inflammation and injury of...

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Bibliographic Details
Main Authors: Chenli Chang, Fengming He, Mingtao Ao, Jun Chen, Tao Yu, Weiyu Li, Baicun Li, Meijuan Fang, Ting Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Pharmacology
Subjects:
Nur77
airway epithelial cells
inflammation
apoptosis
small molecule derivative of flavonoid
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1200110/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1200110/full

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