Increased type-I interferon level is associated with liver damage and fibrosis in primary sclerosing cholangitis

Increased type-I interferon level is associated with liver damage and fibrosis in primary sclerosing cholangitis

Background:. The level of type-I interferons (IFNs) in primary sclerosing cholangitis (PSC) was investigated to evaluate its association with disease activity and progression. Methods:. Bioactive type-I IFNs were evaluated in a murine model of PSC and human patients’ sera using a cell-based reporter...

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Main Authors: Rebekka J.S. Salzmann, Christina Krötz, Tudor Mocan, Lavinia P. Mocan, Cristiana Grapa, Sophia Rottmann, Ramona Reichelt, Cindy M. Keller, Bettina Langhans, Frederik Schünemann, Alexander Pohl, Thomas Böhler, Käthe Bersiner, Marcin Krawczyk, Piotr Milkiewicz, Zeno Sparchez, Frank Lammert, Sebastian Gehlert, Maria A. Gonzalez-Carmona, Arnulf Willms, Christian P. Strassburg, Miroslaw T. Kornek, Leona Dold, Veronika Lukacs-Kornek
Format: Article
Language:English
Published: Wolters Kluwer Health/LWW 2024-03-01
Series:Hepatology Communications
Online Access:http://journals.lww.com/10.1097/HC9.0000000000000380

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http://journals.lww.com/10.1097/HC9.0000000000000380

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