Chimeric antigen receptor-T cells targeting epithelial cell adhesion molecule antigens are effective in the treatment of colorectal cancer

Chimeric antigen receptor-T cells targeting epithelial cell adhesion molecule antigens are effective in the treatment of colorectal cancer

Abstract Objective To construct chimeric antigen receptor (CAR)-T cells targeting epithelial cell adhesion molecule (EpCAM) antigen (anti-EpCAM-CAR-T). Methods A third-generation CAR-T cell construct used a single-chain variable fragment derived from monoclonal antibody against human EpCAM. Peripher...

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Bibliographic Details
Main Authors: Siheng Zeng, Ning Jin, Baofeng Yu, Qing Ren, Zhiqiang Yan, Songtao Fu
Format: Article
Language:English
Published: BMC 2024-08-01
Series:BMC Gastroenterology
Subjects:
Chimeric antigen receptor T cells
Epithelial-specific adhesion molecules
Colorectal cancer
Cellular immunotherapy
Online Access:https://doi.org/10.1186/s12876-024-03286-9

Internet

https://doi.org/10.1186/s12876-024-03286-9

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