First FHM3 mouse model shows spontaneous cortical spreading depolarizations

Abstract Here we show, for the first time, spontaneous cortical spreading depolarization (CSD) events – the electrophysiological correlate of the migraine aura – in animals by using the first generated familial hemiplegic migraine type 3 (FHM3) transgenic mouse model. The mutant mice express L263V‐m...

Full description

Bibliographic Details
Main Authors: Nico A. Jansen, Anisa Dehghani, Margot M. L. Linssen, Cor Breukel, Else A. Tolner, Arn M. J. M. van denMaagdenberg
Format: Article
Language:English
Published: Wiley 2020-01-01
Series:Annals of Clinical and Translational Neurology
Online Access:https://doi.org/10.1002/acn3.50971