First FHM3 mouse model shows spontaneous cortical spreading depolarizations
Abstract Here we show, for the first time, spontaneous cortical spreading depolarization (CSD) events – the electrophysiological correlate of the migraine aura – in animals by using the first generated familial hemiplegic migraine type 3 (FHM3) transgenic mouse model. The mutant mice express L263V‐m...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-01-01
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| Series: | Annals of Clinical and Translational Neurology |
| Online Access: | https://doi.org/10.1002/acn3.50971 |
| _version_ | 1818642236655534080 |
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| author | Nico A. Jansen Anisa Dehghani Margot M. L. Linssen Cor Breukel Else A. Tolner Arn M. J. M. van denMaagdenberg |
| author_facet | Nico A. Jansen Anisa Dehghani Margot M. L. Linssen Cor Breukel Else A. Tolner Arn M. J. M. van denMaagdenberg |
| author_sort | Nico A. Jansen |
| collection | DOAJ |
| description | Abstract Here we show, for the first time, spontaneous cortical spreading depolarization (CSD) events – the electrophysiological correlate of the migraine aura – in animals by using the first generated familial hemiplegic migraine type 3 (FHM3) transgenic mouse model. The mutant mice express L263V‐mutated α1 subunits in voltage‐gated NaV1.1 sodium channels (Scn1aL263V). CSDs consistently propagated from visual to motor cortex, recapitulating what has been shown in patients with migraine with aura. This model may be valuable for the preclinical study of migraine with aura and other diseases in which spreading depolarization is a prominent feature. |
| first_indexed | 2024-12-16T23:39:51Z |
| format | Article |
| id | doaj.art-b4f3e967b6bd4d2488da20753ba68eb9 |
| institution | Directory Open Access Journal |
| issn | 2328-9503 |
| language | English |
| last_indexed | 2024-12-16T23:39:51Z |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Annals of Clinical and Translational Neurology |
| spelling | doaj.art-b4f3e967b6bd4d2488da20753ba68eb92022-12-21T22:11:38ZengWileyAnnals of Clinical and Translational Neurology2328-95032020-01-017113213810.1002/acn3.50971First FHM3 mouse model shows spontaneous cortical spreading depolarizationsNico A. Jansen0Anisa Dehghani1Margot M. L. Linssen2Cor Breukel3Else A. Tolner4Arn M. J. M. van denMaagdenberg5Department of Human Genetics Leiden University Medical Center Leiden The NetherlandsDepartment of Human Genetics Leiden University Medical Center Leiden The NetherlandsDepartment of Human Genetics Leiden University Medical Center Leiden The NetherlandsDepartment of Human Genetics Leiden University Medical Center Leiden The NetherlandsDepartment of Human Genetics Leiden University Medical Center Leiden The NetherlandsDepartment of Human Genetics Leiden University Medical Center Leiden The NetherlandsAbstract Here we show, for the first time, spontaneous cortical spreading depolarization (CSD) events – the electrophysiological correlate of the migraine aura – in animals by using the first generated familial hemiplegic migraine type 3 (FHM3) transgenic mouse model. The mutant mice express L263V‐mutated α1 subunits in voltage‐gated NaV1.1 sodium channels (Scn1aL263V). CSDs consistently propagated from visual to motor cortex, recapitulating what has been shown in patients with migraine with aura. This model may be valuable for the preclinical study of migraine with aura and other diseases in which spreading depolarization is a prominent feature.https://doi.org/10.1002/acn3.50971 |
| spellingShingle | Nico A. Jansen Anisa Dehghani Margot M. L. Linssen Cor Breukel Else A. Tolner Arn M. J. M. van denMaagdenberg First FHM3 mouse model shows spontaneous cortical spreading depolarizations Annals of Clinical and Translational Neurology |
| title | First FHM3 mouse model shows spontaneous cortical spreading depolarizations |
| title_full | First FHM3 mouse model shows spontaneous cortical spreading depolarizations |
| title_fullStr | First FHM3 mouse model shows spontaneous cortical spreading depolarizations |
| title_full_unstemmed | First FHM3 mouse model shows spontaneous cortical spreading depolarizations |
| title_short | First FHM3 mouse model shows spontaneous cortical spreading depolarizations |
| title_sort | first fhm3 mouse model shows spontaneous cortical spreading depolarizations |
| url | https://doi.org/10.1002/acn3.50971 |
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