Extracellular Acidification Alters Lysosomal Trafficking in Human Breast Cancer Cells

Extracellular Acidification Alters Lysosomal Trafficking in Human Breast Cancer Cells

Cancer cells invade by secreting degradative enzymes, which are sequestered in lysosomal vesicles. In this study, the impact of an acidic extracellular environment on lysosome size, number, and distance from the nucleus in human mammary epithelial cells (HMECs) and breast cancer cells of different d...

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Bibliographic Details
Main Authors: Kristine Glunde, Sandra E. Guggino, Meiyappan Solaiyappan, Arvind P. Pathak, Yoshitaka Ichikawa, Zaver M. Bhujwalla
Format: Article
Language:English
Published: Elsevier 2003-11-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Breast cancer
metastasis
fluorescence microscopy
lysosome
trafficking
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558603800374

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http://www.sciencedirect.com/science/article/pii/S1476558603800374

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