A structure and knowledge-based combinatorial approach to engineering universal scFv antibodies against influenza M2 protein

A structure and knowledge-based combinatorial approach to engineering universal scFv antibodies against influenza M2 protein

Abstract Background The influenza virus enters the host via hemagglutinin protein binding to cell surface sialic acid. Receptor-mediated endocytosis is followed by viral nucleocapsid uncoating for replication aided by the transmembrane viral M2 proton ion channel. M2 ectodomain (M2e) is a potential...

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Bibliographic Details
Main Authors: Ujjwal Kumar, Priya Goyal, Zaid K. Madni, Kajal Kamble, Vineet Gaur, Maitreyi S. Rajala, Dinakar M. Salunke
Format: Article
Language:English
Published: BMC 2023-07-01
Series:Journal of Biomedical Science
Subjects:
Influenza virus
M2 ion channel protein and M2e dimerization
Naive human antibody scFv library
Co-crystallization
Virus regression
Online Access:https://doi.org/10.1186/s12929-023-00950-2

Internet

https://doi.org/10.1186/s12929-023-00950-2

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