A structure and knowledge-based combinatorial approach to engineering universal scFv antibodies against influenza M2 protein
Abstract Background The influenza virus enters the host via hemagglutinin protein binding to cell surface sialic acid. Receptor-mediated endocytosis is followed by viral nucleocapsid uncoating for replication aided by the transmembrane viral M2 proton ion channel. M2 ectodomain (M2e) is a potential...
Main Authors: | Ujjwal Kumar, Priya Goyal, Zaid K. Madni, Kajal Kamble, Vineet Gaur, Maitreyi S. Rajala, Dinakar M. Salunke |
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Format: | Article |
Language: | English |
Published: |
BMC
2023-07-01
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Series: | Journal of Biomedical Science |
Subjects: | |
Online Access: | https://doi.org/10.1186/s12929-023-00950-2 |
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