Phosphorylation and Dephosphorylation of Beta-Amyloid Peptide in Model Cell Cultures: The Role of Cellular Protein Kinases and Phosphatases

Phosphorylation and Dephosphorylation of Beta-Amyloid Peptide in Model Cell Cultures: The Role of Cellular Protein Kinases and Phosphatases

Phosphorylation of beta-amyloid peptide (Aβ) at the Ser8 residue affects its neurotoxicity, metal-dependent oligomerisation, amyloidogenicity, and other pathogenic properties. Phosphorylated Aβ (pS8-Aβ) was detected in vivo in AD model mice and in the brains of patients with AD. However, the pS8-Aβ...

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Bibliographic Details
Main Authors: Evgeny P. Barykin, Dmitry V. Yanvarev, Maria A. Strelkova, Vladimir T. Valuev-Elliston, Kseniya B. Varshavskaya, Vladimir A. Mitkevich, Alexander A. Makarov
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Life
Subjects:
beta-amyloid
phosphorylation
casein kinase 2
blood–brain barrier
radiolabelling
phosphatase
Online Access:https://www.mdpi.com/2075-1729/13/1/147

Internet

https://www.mdpi.com/2075-1729/13/1/147

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