Acetate supplementation restores cognitive deficits caused by ARID1A haploinsufficiency in excitatory neurons

Acetate supplementation restores cognitive deficits caused by ARID1A haploinsufficiency in excitatory neurons

Abstract Mutations in AT‐rich interactive domain‐containing protein 1A (ARID1A) cause Coffin‐Siris syndrome (CSS), a rare genetic disorder that results in mild to severe intellectual disabilities. However, the biological role of ARID1A in the brain remains unclear. In this study, we report that the...

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Bibliographic Details
Main Authors: Pei‐Pei Liu, Shang‐Kun Dai, Ting‐Wei Mi, Gang‐Bin Tang, Zhuo Wang, Hui Wang, Hong‐Zhen Du, Yi Tang, Zhao‐Qian Teng, Chang‐Mei Liu
Format: Article
Language:English
Published: Springer Nature 2022-12-01
Series:EMBO Molecular Medicine
Subjects:
acetate
ARID1A
cognitive deficit
excitatory neurons
SWI/SNF
Online Access:https://doi.org/10.15252/emmm.202215795

Internet

https://doi.org/10.15252/emmm.202215795

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