An Orally Bioavailable (Mice) Prodrug of Glutathione

L-Cysteine-glutathione mixed disulfide (CySSG), a prodrug of glutathione (GSH), was found to be orally bioavailable in mice, and protected mice against a toxic dose of acetaminophen. If oral bioavailability can also be demonstrated in humans, a wide range of applicability for CySSG can be envisioned...

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Bibliographic Details
Main Authors: Daune L. Crankshaw, Jacquie E. Briggs, Robert Vince, Herbert T. Nagasawa
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Antioxidants
Subjects:
Online Access:https://www.mdpi.com/2076-3921/10/6/939