Activation of RAAS in a rat model of liver cirrhosis: no effect of losartan on renal sodium excretion

Activation of RAAS in a rat model of liver cirrhosis: no effect of losartan on renal sodium excretion

Abstract Background Liver cirrhosis is characterized by avid sodium retention where the activation of the renin angiotensin aldosterone system (RAAS) is considered to be the hallmark of the sodium retaining mechanisms. The direct effect of angiotensin II (ANGII) on the AT-1 receptor in the proximal...

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Bibliographic Details
Main Authors: A. D. Fialla, O. B. Schaffalitzky de Muckadell, P. Bie, H. C. Thiesson
Format: Article
Language:English
Published: BMC 2018-09-01
Series:BMC Nephrology
Subjects:
Sodium retention
Bile duct ligation
ANGII antagonists
Liver cirrhosis
Aldosterone
Online Access:http://link.springer.com/article/10.1186/s12882-018-1039-6

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http://link.springer.com/article/10.1186/s12882-018-1039-6

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