Specific NLRP3 Inflammasome Assembling and Regulation in Neutrophils: Relevance in Inflammatory and Infectious Diseases
The NLRP3 inflammasome is a cytosolic multimeric protein platform that leads to the activation of the protease zymogen, caspase-1 (CASP1). Inflammasome activation mediates the proteolytic activation of pro-inflammatory cytokines (IL-1β and IL-18) and program cell death called pyroptosis. The pyropto...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/11/7/1188 |
| _version_ | 1797439934405017600 |
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| author | Christophe Paget Emilie Doz-Deblauwe Nathalie Winter Benoit Briard |
| author_facet | Christophe Paget Emilie Doz-Deblauwe Nathalie Winter Benoit Briard |
| author_sort | Christophe Paget |
| collection | DOAJ |
| description | The NLRP3 inflammasome is a cytosolic multimeric protein platform that leads to the activation of the protease zymogen, caspase-1 (CASP1). Inflammasome activation mediates the proteolytic activation of pro-inflammatory cytokines (IL-1β and IL-18) and program cell death called pyroptosis. The pyroptosis is mediated by the protein executioner Gasdermin D (GSDMD), which forms pores at the plasma membrane to facilitate IL-1β/IL-18 secretion and causes pyroptosis. The NLRP3 inflammasome is activated in response to a large number of pathogenic and sterile insults. However, an uncontrolled inflammasome activation may drive inflammation-associated diseases. Initially, inflammasome-competent cells were believed to be limited to macrophages, dendritic cells (DC), and monocytes. However, emerging evidence indicates that neutrophils can assemble inflammasomes in response to various stimuli with functional relevance. Interestingly, the regulation of inflammasome in neutrophils appears to be unconventional. This review provides a broad overview of the role and regulation of inflammasomes—and more specifically NLRP3—in neutrophils. |
| first_indexed | 2024-03-09T11:59:54Z |
| format | Article |
| id | doaj.art-b4fbd2d0fbe14851bdf6bce61adc9206 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T11:59:54Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-b4fbd2d0fbe14851bdf6bce61adc92062023-11-30T23:04:40ZengMDPI AGCells2073-44092022-04-01117118810.3390/cells11071188Specific NLRP3 Inflammasome Assembling and Regulation in Neutrophils: Relevance in Inflammatory and Infectious DiseasesChristophe Paget0Emilie Doz-Deblauwe1Nathalie Winter2Benoit Briard3Centre d’Etude des Pathologies Respiratoires, UMR1100, Inserm (Institut National de la Santé et de la Recherche Médicale), 37012 Tours, FranceINRAe (Institut National de la Recherche pour l’Agriculture, l’Alimentation et l’Environnement), Université de Tours, ISP, 37380 Nouzilly, FranceINRAe (Institut National de la Recherche pour l’Agriculture, l’Alimentation et l’Environnement), Université de Tours, ISP, 37380 Nouzilly, FranceCentre d’Etude des Pathologies Respiratoires, UMR1100, Inserm (Institut National de la Santé et de la Recherche Médicale), 37012 Tours, FranceThe NLRP3 inflammasome is a cytosolic multimeric protein platform that leads to the activation of the protease zymogen, caspase-1 (CASP1). Inflammasome activation mediates the proteolytic activation of pro-inflammatory cytokines (IL-1β and IL-18) and program cell death called pyroptosis. The pyroptosis is mediated by the protein executioner Gasdermin D (GSDMD), which forms pores at the plasma membrane to facilitate IL-1β/IL-18 secretion and causes pyroptosis. The NLRP3 inflammasome is activated in response to a large number of pathogenic and sterile insults. However, an uncontrolled inflammasome activation may drive inflammation-associated diseases. Initially, inflammasome-competent cells were believed to be limited to macrophages, dendritic cells (DC), and monocytes. However, emerging evidence indicates that neutrophils can assemble inflammasomes in response to various stimuli with functional relevance. Interestingly, the regulation of inflammasome in neutrophils appears to be unconventional. This review provides a broad overview of the role and regulation of inflammasomes—and more specifically NLRP3—in neutrophils.https://www.mdpi.com/2073-4409/11/7/1188inflammasomeneutrophilsNLRP3caspase-1caspase-11IL-1β |
| spellingShingle | Christophe Paget Emilie Doz-Deblauwe Nathalie Winter Benoit Briard Specific NLRP3 Inflammasome Assembling and Regulation in Neutrophils: Relevance in Inflammatory and Infectious Diseases Cells inflammasome neutrophils NLRP3 caspase-1 caspase-11 IL-1β |
| title | Specific NLRP3 Inflammasome Assembling and Regulation in Neutrophils: Relevance in Inflammatory and Infectious Diseases |
| title_full | Specific NLRP3 Inflammasome Assembling and Regulation in Neutrophils: Relevance in Inflammatory and Infectious Diseases |
| title_fullStr | Specific NLRP3 Inflammasome Assembling and Regulation in Neutrophils: Relevance in Inflammatory and Infectious Diseases |
| title_full_unstemmed | Specific NLRP3 Inflammasome Assembling and Regulation in Neutrophils: Relevance in Inflammatory and Infectious Diseases |
| title_short | Specific NLRP3 Inflammasome Assembling and Regulation in Neutrophils: Relevance in Inflammatory and Infectious Diseases |
| title_sort | specific nlrp3 inflammasome assembling and regulation in neutrophils relevance in inflammatory and infectious diseases |
| topic | inflammasome neutrophils NLRP3 caspase-1 caspase-11 IL-1β |
| url | https://www.mdpi.com/2073-4409/11/7/1188 |
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