Risk of malignancy in cytologically indeterminate thyroid nodules harboring thyroid stimulating hormone receptor mutations

Risk of malignancy in cytologically indeterminate thyroid nodules harboring thyroid stimulating hormone receptor mutations

ObjectivesTo evaluate the frequency and risk of malignancy of TSHRpI568T mutations discovered in indeterminate thyroid nodules (ITN) within the Veracyte CLIA laboratory undergoing Afirma® Genomic Sequencing Classifier (GSC) testing, and to evaluate a broader cohort of TSHR variants and their categor...

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Bibliographic Details
Main Authors: Dorota Whitmer, John E. Phay, Shelby Holt, Benjamin O’Donnell, Jay Nguyen, Dennis Joseph, Anthony Chi, Shuyang Wu, Yangyang Hao, Jing Huang, Joshua P. Klopper, Richard T. Kloos, Giulia C. Kennedy, Joyce Shin
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Endocrinology
Subjects:
thyroid nodule
molecular diagnosis
TSH receptor (TSHR)
Afirma ®
thyroid cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2022.1073592/full

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https://www.frontiersin.org/articles/10.3389/fendo.2022.1073592/full

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