Conditional knockout of Mn superoxide dismutase in postnatal motor neurons reveals resistance to mitochondrial generated superoxide radicals

Conditional knockout of Mn superoxide dismutase in postnatal motor neurons reveals resistance to mitochondrial generated superoxide radicals

Mitochondrial dysfunction and oxidative damage are implicated in the pathogenesis of neurodegenerative disease. Mice deficient in the mitochondrial form of superoxide dismutase (SOD2) die during embryonic or early postnatal development, precluding analysis of a pathological role for superoxide in ad...

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Bibliographic Details
Main Authors: Hidemi Misawa, Kazuko Nakata, Junko Matsuura, Yasuhiro Moriwaki, Koichiro Kawashima, Takahiko Shimizu, Takuji Shirasawa, Ryosuke Takahashi
Format: Article
Language:English
Published: Elsevier 2006-07-01
Series:Neurobiology of Disease
Subjects:
Motor neurons
Oxidative stress
Mitochondria
Nerve injury
Conditional knockout
SOD2
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996106000507

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http://www.sciencedirect.com/science/article/pii/S0969996106000507

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