2,4-Diacetylphloroglucinol Reduces Beta-Amyloid Production and Secretion by Regulating ADAM10 and Intracellular Trafficking in Cellular and Animal Models of Alzheimer’s Disease

2,4-Diacetylphloroglucinol Reduces Beta-Amyloid Production and Secretion by Regulating ADAM10 and Intracellular Trafficking in Cellular and Animal Models of Alzheimer’s Disease

There is currently no effective treatment against Alzheimer’s disease (AD), although many strategies have been applied to reduce beta-amyloid (Aβ) levels. Here, we investigated 2,4-diacetylphloroglucinol (DAPG) effects on Aβ levels and mechanisms of action. DAPG was the most effective phloroglucinol...

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Bibliographic Details
Main Authors: Bong-Geum Jang, Boyoung Choi, Suyeon Kim, Duk-Shin Lee, Jisun Lee, Young Ho Koh, Sangmee Ahn Jo, Ji-Eun Kim, Tae-Cheon Kang, Min-Ju Kim
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Cells
Subjects:
Alzheimer’s disease
beta-amyloid
2,4-diacetylphloroglucinol
alpha-secretase
intracellular trafficking
Online Access:https://www.mdpi.com/2073-4409/11/16/2585

Internet

https://www.mdpi.com/2073-4409/11/16/2585

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