The Long Non-coding RNAs: Paramount Regulators of the NLRP3 Inflammasome
The NOD LRR pyrin domain containing protein 3 (NLRP3) inflammasome is a cytosolic multi-proteins conglomerate with intrinsic ATPase activity. Their predominant presence in the immune cells emphasizes its significant role in immune response. The downstream effector proteins IL-1β and IL-18 are respon...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-09-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2020.569524/full |
| _version_ | 1818872823954800640 |
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| author | Mridula P. Menon Kuo-Feng Hua Kuo-Feng Hua Kuo-Feng Hua |
| author_facet | Mridula P. Menon Kuo-Feng Hua Kuo-Feng Hua Kuo-Feng Hua |
| author_sort | Mridula P. Menon |
| collection | DOAJ |
| description | The NOD LRR pyrin domain containing protein 3 (NLRP3) inflammasome is a cytosolic multi-proteins conglomerate with intrinsic ATPase activity. Their predominant presence in the immune cells emphasizes its significant role in immune response. The downstream effector proteins IL-1β and IL-18 are responsible for the biological functions of the NLRP3 inflammasome upon encountering the alarmins and microbial ligands. Although the NLRP3 inflammasome is essential for host defense during infections, uncontrolled activation and overproduction of IL-1β and IL-18 increase the risk of developing autoimmune and metabolic disorders. Emerging evidences suggest the action of lncRNAs in regulating the activity of NLRP3 inflammasome in various disease conditions. The long non-coding RNA (lncRNA) is an emerging field of study and evidence on their regulatory role in various diseases is grabbing attention. Recent studies emphasize the functions of lncRNAs in the fine control of the NLRP3 inflammasome at nuclear and cytoplasmic levels by interfering in chromatin architecture, gene transcription and translation. Recently, lncRNAs are also found to control the activity of various regulators of NLRP3 inflammasome. Understanding the precise role of lncRNA in controlling the activity of NLRP3 inflammasome helps us to design targeted therapies for multiple inflammatory diseases. The present review is a novel attempt to consolidate the substantial role of lncRNAs in the regulation of the NLRP3 inflammasome. A deeper insight on the NLRP3 inflammasome regulation by lncRNAs will help in developing targeted and beneficial therapeutics in the future. |
| first_indexed | 2024-12-19T12:44:56Z |
| format | Article |
| id | doaj.art-b5004cf2655e4c1ba11d72ae6a276232 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-19T12:44:56Z |
| publishDate | 2020-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-b5004cf2655e4c1ba11d72ae6a2762322022-12-21T20:20:48ZengFrontiers Media S.A.Frontiers in Immunology1664-32242020-09-011110.3389/fimmu.2020.569524569524The Long Non-coding RNAs: Paramount Regulators of the NLRP3 InflammasomeMridula P. Menon0Kuo-Feng Hua1Kuo-Feng Hua2Kuo-Feng Hua3Department of Biotechnology and Animal Science, National Ilan University, Yilan, TaiwanDepartment of Biotechnology and Animal Science, National Ilan University, Yilan, TaiwanDepartment of Pathology, Tri-Service General Hospital, National Defense Medical Center, Taipei, TaiwanDepartment of Medical Research, China Medical University Hospital, China Medical University, Taichung, TaiwanThe NOD LRR pyrin domain containing protein 3 (NLRP3) inflammasome is a cytosolic multi-proteins conglomerate with intrinsic ATPase activity. Their predominant presence in the immune cells emphasizes its significant role in immune response. The downstream effector proteins IL-1β and IL-18 are responsible for the biological functions of the NLRP3 inflammasome upon encountering the alarmins and microbial ligands. Although the NLRP3 inflammasome is essential for host defense during infections, uncontrolled activation and overproduction of IL-1β and IL-18 increase the risk of developing autoimmune and metabolic disorders. Emerging evidences suggest the action of lncRNAs in regulating the activity of NLRP3 inflammasome in various disease conditions. The long non-coding RNA (lncRNA) is an emerging field of study and evidence on their regulatory role in various diseases is grabbing attention. Recent studies emphasize the functions of lncRNAs in the fine control of the NLRP3 inflammasome at nuclear and cytoplasmic levels by interfering in chromatin architecture, gene transcription and translation. Recently, lncRNAs are also found to control the activity of various regulators of NLRP3 inflammasome. Understanding the precise role of lncRNA in controlling the activity of NLRP3 inflammasome helps us to design targeted therapies for multiple inflammatory diseases. The present review is a novel attempt to consolidate the substantial role of lncRNAs in the regulation of the NLRP3 inflammasome. A deeper insight on the NLRP3 inflammasome regulation by lncRNAs will help in developing targeted and beneficial therapeutics in the future.https://www.frontiersin.org/article/10.3389/fimmu.2020.569524/fulllncRNAsNLRP3 inflammasomenuclear regulationcytoplasmic regulationchromatin remodelingtranscriptional regulation |
| spellingShingle | Mridula P. Menon Kuo-Feng Hua Kuo-Feng Hua Kuo-Feng Hua The Long Non-coding RNAs: Paramount Regulators of the NLRP3 Inflammasome Frontiers in Immunology lncRNAs NLRP3 inflammasome nuclear regulation cytoplasmic regulation chromatin remodeling transcriptional regulation |
| title | The Long Non-coding RNAs: Paramount Regulators of the NLRP3 Inflammasome |
| title_full | The Long Non-coding RNAs: Paramount Regulators of the NLRP3 Inflammasome |
| title_fullStr | The Long Non-coding RNAs: Paramount Regulators of the NLRP3 Inflammasome |
| title_full_unstemmed | The Long Non-coding RNAs: Paramount Regulators of the NLRP3 Inflammasome |
| title_short | The Long Non-coding RNAs: Paramount Regulators of the NLRP3 Inflammasome |
| title_sort | long non coding rnas paramount regulators of the nlrp3 inflammasome |
| topic | lncRNAs NLRP3 inflammasome nuclear regulation cytoplasmic regulation chromatin remodeling transcriptional regulation |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2020.569524/full |
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