Scalable Production of Human Mesenchymal Stromal Cell-Derived Extracellular Vesicles Under Serum-/Xeno-Free Conditions in a Microcarrier-Based Bioreactor Culture System

Scalable Production of Human Mesenchymal Stromal Cell-Derived Extracellular Vesicles Under Serum-/Xeno-Free Conditions in a Microcarrier-Based Bioreactor Culture System

Mesenchymal stromal cells (MSC) hold great promise for tissue engineering and cell-based therapies due to their multilineage differentiation potential and intrinsic immunomodulatory and trophic activities. Over the past years, increasing evidence has proposed extracellular vesicles (EVs) as mediator...

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Bibliographic Details
Main Authors: Miguel de Almeida Fuzeta, Nuno Bernardes, Filipa D. Oliveira, Ana Catarina Costa, Ana Fernandes-Platzgummer, José Paulo Farinha, Carlos A. V. Rodrigues, Sunghoon Jung, Rong-Jeng Tseng, William Milligan, Brian Lee, Miguel A. R. B. Castanho, Diana Gaspar, Joaquim M. S. Cabral, Cláudia Lobato da Silva
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
extracellular vesicles
mesenchymal stromal cells (MSC)
scalable production
bioreactors
serum-/xenogeneic-free
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2020.553444/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2020.553444/full

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