Zmiz1 is required for mature β-cell function and mass expansion upon high fat feeding

Zmiz1 is required for mature β-cell function and mass expansion upon high fat feeding

Objective: Identifying the transcripts which mediate genetic association signals for type 2 diabetes (T2D) is critical to understand disease mechanisms. Studies in pancreatic islets support the transcription factor ZMIZ1 as a transcript underlying a T2D GWAS signal, but how it influences T2D risk is...

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Bibliographic Details
Main Authors: Tamadher A. Alghamdi, Nicole A.J. Krentz, Nancy Smith, Aliya F. Spigelman, Varsha Rajesh, Alokkumar Jha, Mourad Ferdaoussi, Kunimasa Suzuki, Jing Yang, Jocelyn E. Manning Fox, Han Sun, Zijie Sun, Anna L. Gloyn, Patrick E. MacDonald
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Molecular Metabolism
Subjects:
Islets of langerhans
Insulin
Secretion
Diabetes
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877822001909

Internet

http://www.sciencedirect.com/science/article/pii/S2212877822001909

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