Molecular Cloning and Functional Analysis of Gene Clusters for the Biosynthesis of Indole-Diterpenes in Penicillium crustosum and P. janthinellum

The penitremane and janthitremane families of indole-diterpenes are abundant natural products synthesized by Penicillium crustosum and P. janthinellum. Using a combination of PCR, cosmid library screening, and Illumina sequencing we have identified gene clusters encoding enzymes for the synthesis of...

Full description

Bibliographic Details
Main Authors: Matthew J. Nicholson, Carla J. Eaton, Cornelia Stärkel, Brian A. Tapper, Murray P. Cox, Barry Scott
Format: Article
Language:English
Published: MDPI AG 2015-07-01
Series:Toxins
Subjects:
Online Access:http://www.mdpi.com/2072-6651/7/8/2701