Opioid-Induced Hyperalgesia in Chronic Pain Patients and the Mitigating Effects of Gabapentin

Opioid-Induced Hyperalgesia in Chronic Pain Patients and the Mitigating Effects of Gabapentin

Chronic pain patients receiving opioid drugs are at risk for opioid-induced hyperalgesia (OIH), wherein opioid pain medication leads to a paradoxical pain state. OIH involves central sensitization of primary and secondary afferent neurons in the dorsal horn and dorsal root ganglion, similar to neuro...

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Bibliographic Details
Main Authors: Nicoleta eStoicea, Daric eRussell, Greg eWeidner, Michael eDurda, Nicholas Christopher Joseph, Jeffrey eYu, Sergio Daniel Bergese
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-05-01
Series:Frontiers in Pharmacology
Subjects:
NMDA
neuropathic pain
allodynia
Opiods
gabapentin
VGCCs
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00104/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00104/full

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