Linker-extended native cyanovirin-N facilitates PEGylation and potently inhibits HIV-1 by targeting the glycan ligand.

Linker-extended native cyanovirin-N facilitates PEGylation and potently inhibits HIV-1 by targeting the glycan ligand.

Cyanovirin-N (CVN) potently inhibits human immunodeficiency virus type 1 (HIV-1) infection, but both cytotoxicity and immunogenicity have hindered the translation of this protein into a viable therapeutic. A molecular docking analysis suggested that up to 12 residues were involved in the interaction...

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Bibliographic Details
Main Authors: Jia Chen, Dane Huang, Wei Chen, Chaowan Guo, Bo Wei, Chongchao Wu, Zhou Peng, Jun Fan, Zhibo Hou, Yongsheng Fang, Yifei Wang, Kaio Kitazato, Guoying Yu, Chunbin Zou, Chuiwen Qian, Sheng Xiong
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3903522?pdf=render

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http://europepmc.org/articles/PMC3903522?pdf=render

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