Quantitative analysis of how Myc controls T cell proteomes and metabolic pathways during T cell activation

T cell expansion and differentiation are critically dependent on the transcription factor c-Myc (Myc). Herein we use quantitative mass-spectrometry to reveal how Myc controls antigen receptor driven cell growth and proteome restructuring in murine T cells. Analysis of copy numbers per cell of &g...

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Detalles Bibliográficos
Main Authors: Julia M Marchingo, Linda V Sinclair, Andrew JM Howden, Doreen A Cantrell
Formato: Artigo
Idioma:English
Publicado: eLife Sciences Publications Ltd 2020-02-01
Series:eLife
Subjects:
Acceso en liña:https://elifesciences.org/articles/53725