Dry Amorphization of Itraconazole Using Mesoporous Silica and Twin-Screw Technology

Dry Amorphization of Itraconazole Using Mesoporous Silica and Twin-Screw Technology

<b>Background/Objectives:</b> Amorphization of an active pharmaceutical ingredient (API) can improve its dissolution and enhance bioavailability. Avoiding solvents for drug amorphization is beneficial due to environmental issues and potential solvent residues in the final product. <b&...

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Bibliographic Details
Main Authors: Margarethe Richter, Simon Welzmiller, Fred Monsuur, Annika R. Völp, Joachim Quadflieg
Format: Article
Language:English
Published: MDPI AG 2024-10-01
Series:Pharmaceutics
Subjects:
twin-screw granulation
twin-screw extruder
API amorphization
solubility enhancement
mesoporous silica
continuous manufacturing
Online Access:https://www.mdpi.com/1999-4923/16/11/1368

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https://www.mdpi.com/1999-4923/16/11/1368

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