LOX-1 Deletion Attenuates Myocardial Fibrosis in the Aged Mice, Particularly Those With Hypertension

LOX-1 Deletion Attenuates Myocardial Fibrosis in the Aged Mice, Particularly Those With Hypertension

Background: Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is a transmembrane glycoprotein that mediates uptake of oxidized low-density lipoprotein (ox-LDL) into cells. Previous studies had shown that LOX-1 deletion had a potential to inhibit cardiac fibrosis in mouse models of hype...

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Bibliographic Details
Main Authors: Xiao Li, Xihe Tang, Bo Liu, Jinghang Zhang, Yongxi Zhang, Hefan Lv, Dongling Liu, Jawahar L. Mehta, Xianwei Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
myocardial fibrosis
aging
hypertension
collagens
lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1)
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2021.736215/full

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https://www.frontiersin.org/articles/10.3389/fcvm.2021.736215/full

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