CNPase, a 2′,3′-Cyclic-nucleotide 3′-phosphodiesterase, as a Therapeutic Target to Attenuate Cardiac Hypertrophy by Enhancing Mitochondrial Energy Production

CNPase, a 2′,3′-Cyclic-nucleotide 3′-phosphodiesterase, as a Therapeutic Target to Attenuate Cardiac Hypertrophy by Enhancing Mitochondrial Energy Production

Heart failure is the end-stage of all cardiovascular diseases with a ~25% 5-year survival rate, and insufficient mitochondrial energy production to meet myocardial demand is the hallmark of heart failure. Mitochondrial components involved in the regulation of ATP production remain to be fully elucid...

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Bibliographic Details
Main Authors: Keai Sinn Tan, Dongfang Wang, Ziqiang Lu, Yihan Zhang, Sixu Li, Yue Lin, Wen Tan
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:International Journal of Molecular Sciences
Subjects:
CNPase
heart failure animal model
zebrafish
CRISPR-Cas9
mitochondrial energy production
Online Access:https://www.mdpi.com/1422-0067/22/19/10806

Internet

https://www.mdpi.com/1422-0067/22/19/10806

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