NBTXR3 improves the efficacy of immunoradiotherapy combining nonfucosylated anti-CTLA4 in an anti-PD1 resistant lung cancer model

NBTXR3 improves the efficacy of immunoradiotherapy combining nonfucosylated anti-CTLA4 in an anti-PD1 resistant lung cancer model

The efficacy of immunoradiotherapy consisting of radiation therapy and immune checkpoint blockade relies on effectively promoting the systemic antitumor immune response’s activation while simultaneously reducing local factors favoring immune suppression. We previously demonstrated that NBTXR3, a nan...

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Bibliographic Details
Main Authors: Yun Hu, Sébastien Paris, Genevieve Bertolet, Hampartsoum B. Barsoumian, Qi Wang, Jordan Da Silva, Nalini B. Patel, Nguyen Nguyen, Denaha J. Doss, Ailing Huang, Ethan Hsu, Claudia S. Kettlun Leyton, Tiffany A. Voss, Fatemeh Masrorpour, Carola Leuschner, Jordan T. Pietz, Nahum Puebla-Osorio, Saumil Gandhi, Quynh-Nhu Nguyen, Jing Wang, Maria Angelica Cortez, James W. Welsh
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Immunology
Subjects:
immunoradiotherapy
NBTXR3 nanoparticle
immume checkpoint blockade
abscopal effect
lung cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1022011/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.1022011/full

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