Genomic Characterization of Mutli-Drug Resistant Pseudomonas aeruginosa Clinical Isolates: Evaluation and Determination of Ceftolozane/Tazobactam Activity and Resistance Mechanisms

Genomic Characterization of Mutli-Drug Resistant Pseudomonas aeruginosa Clinical Isolates: Evaluation and Determination of Ceftolozane/Tazobactam Activity and Resistance Mechanisms

Resistance to ceftolozane/tazobactam (C/T) in Pseudomonas aeruginosa is a health concern. In this study, we conducted a whole-genome-based molecular characterization to correlate resistance patterns and β-lactamases with C/T resistance among multi-drug resistant P. aeruginosa clinical isolates. Resi...

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Bibliographic Details
Main Authors: Ibrahim Bitar, Tamara Salloum, Georgi Merhi, Jaroslav Hrabak, George F. Araj, Sima Tokajian
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
ceftolozane/tazobactam (C/T)
Pseudomonas aeruginosa
AmpC
porins
beta lactamases
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2022.922976/full

Internet

https://www.frontiersin.org/articles/10.3389/fcimb.2022.922976/full

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