Epigenetic regulation of epithelial-mesenchymal transition: focusing on hypoxia and TGF-β signaling

Epigenetic regulation of epithelial-mesenchymal transition: focusing on hypoxia and TGF-β signaling

Abstract Epithelial-mesenchymal transition (EMT) is an important process triggered during cancer metastasis. Regulation of EMT is mostly initiated by outside signalling, including TGF-β, growth factors, Notch ligand, Wnt, and hypoxia. Many signalling pathways have been delineated to explain the mole...

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Bibliographic Details
Main Authors: Yueh-Te Lin, Kou-Juey Wu
Format: Article
Language:English
Published: BMC 2020-03-01
Series:Journal of Biomedical Science
Subjects:
Epithelial-mesenchymal transition
Hypoxia
TGF-β
Epigenetic regulation
HIF-1α
HDAC3
Online Access:http://link.springer.com/article/10.1186/s12929-020-00632-3

Internet

http://link.springer.com/article/10.1186/s12929-020-00632-3

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