Plasticity and therapeutic potential of cAMP and cGMP-specific phosphodiesterases in Toxoplasma gondii

Plasticity and therapeutic potential of cAMP and cGMP-specific phosphodiesterases in Toxoplasma gondii

Toxoplasma gondii is a common zoonotic protozoan pathogen adapted to intracellular parasitism in many host cells of diverse organisms. Our previous work has identified 18 cyclic nucleotide phosphodiesterase (PDE) proteins encoded by the parasite genome, of which 11 are expressed during the lytic cyc...

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Bibliographic Details
Main Authors: Kim Chi Vo, Liberta Ruga, Olympia Ekaterini Psathaki, Rico Franzkoch, Ute Distler, Stefan Tenzer, Michael Hensel, Peter Hegemann, Nishith Gupta
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Apicomplexa
Phosphodiesterase
cAMP & cGMP signaling
Lytic cycle
Tachyzoite
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037022004275

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http://www.sciencedirect.com/science/article/pii/S2001037022004275

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