Molecular Evolution of MDM1, a "Duplication-Resistant" Gene in Vertebrates.

The mouse double minute 1 (Mdm1) gene was first reported and cloned in mouse tumor cell lines as an oncogene candidate. Later, it was found that mutation of Mdm1 might cause age-related retinal degeneration 2 in mice by genetic linkage analysis. Additionally, the MDM1 protein was found to be express...

Full description

Bibliographic Details
Main Authors: Monica R Hensley, Rhys F M Chua, Yuk Fai Leung, Jer-Yen Yang, GuangJun Zhang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5033493?pdf=render