Exploring Morphine-Triggered PKC-Targets and Their Interaction with Signaling Pathways Leading to Pain via TrkA

Exploring Morphine-Triggered PKC-Targets and Their Interaction with Signaling Pathways Leading to Pain via TrkA

It is well accepted that treatment of chronic pain with morphine leads to μ opioid receptor (MOR) desensitization and the development of morphine tolerance. MOR activation by the selective peptide agonist, D-Ala2, N-MePhe4, Gly-ol]-enkephalin(DAMGO), leads to robust G protein receptor kinase...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: Darlene A. Pena, Mariana Lemos Duarte, Dimitrius T. Pramio, Lakshmi A. Devi, Deborah Schechtman
Format: Artikel
Sprache:English
Veröffentlicht: MDPI AG 2018-10-01
Schriftenreihe:Proteomes
Schlagworte:
morphine
opioid receptors
conformational antibody
analgesia
GPCR signaling
Online Zugang:http://www.mdpi.com/2227-7382/6/4/39

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http://www.mdpi.com/2227-7382/6/4/39

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