Clozapine Long-Term Treatment Might Reduce Epigenetic Age Through Hypomethylation of Longevity Regulatory Pathways Genes

Clozapine Long-Term Treatment Might Reduce Epigenetic Age Through Hypomethylation of Longevity Regulatory Pathways Genes

Long-term studies have shown significantly lower mortality rates in patients with continuous clozapine (CLZ) treatment than other antipsychotics. We aimed to evaluate epigenetic age and DNA methylome differences between CLZ-treated patients and those without psychopharmacological treatment. The DNA...

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Bibliographic Details
Main Authors: Blanca Estela Pérez-Aldana, José Jaime Martínez-Magaña, Yerye Gibrán Mayén-Lobo, David José Dávila-Ortiz de Montellano, Carlos Luis Aviña-Cervantes, Alberto Ortega-Vázquez, Alma Delia Genis-Mendoza, Emmanuel Sarmiento, Ernesto Soto-Reyes, Isela Esther Juárez-Rojop, Carlos Alfonso Tovilla-Zarate, Thelma Beatriz González-Castro, Humberto Nicolini, Marisol López-López, Nancy Monroy-Jaramillo
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Psychiatry
Subjects:
DNA methylome
clozapine
psychotic disorders
epigenetic age
longevity
Online Access:https://www.frontiersin.org/articles/10.3389/fpsyt.2022.870656/full

Internet

https://www.frontiersin.org/articles/10.3389/fpsyt.2022.870656/full

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