Developing an animal model to detect drug–drug interactions impacting drug-induced respiratory depression

Developing an animal model to detect drug–drug interactions impacting drug-induced respiratory depression

Opioids and benzodiazepines were frequently co-prescribed to patients with pain and psychiatric or neurological disorders; however, co-prescription of these drugs increased the risk for severe respiratory depression and death. Consequently, the U.S. Food and Drug Administration added boxed label war...

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Bibliographic Details
Main Authors: Lin Xu, Ashok Chockalingam, Sharron Stewart, Katherine Shea, Murali K. Matta, Suresh Narayanasamy, Nageswara R. Pilli, Donna A. Volpe, James Weaver, Hao Zhu, Michael C. Davis, David G. Strauss, Rodney Rouse
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Toxicology Reports
Subjects:
Animal model
Opioids
Sedating psychotropic drugs
Respiratory depression
Arterial partial pressure of oxygen
Arterial partial pressure of carbon dioxide
Online Access:http://www.sciencedirect.com/science/article/pii/S2214750019303804

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http://www.sciencedirect.com/science/article/pii/S2214750019303804

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