Identifying Features of Cardiac Disease Phenotypes Based on Mechanical Function in a Catecholaminergic Polymorphic Ventricular Tachycardia Model

Identifying Features of Cardiac Disease Phenotypes Based on Mechanical Function in a Catecholaminergic Polymorphic Ventricular Tachycardia Model

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is characterized by an arrhythmogenic mechanism involving disruption of calcium handling. This genetic disease can lead to sudden death in children and young adults during physical or emotional stress. Prior CPVT studies have focused on ca...

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Bibliographic Details
Main Authors: A. Stempien, M. Josvai, W. J. de Lange, J. J. Hernandez, J. Notbohm, T. J. Kamp, H. H. Valdivia, L. L. Eckhardt, K. R. Maginot, J. C. Ralphe, W. C. Crone
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
iPSC-cardiomyocytes
disease model
contraction rate
DIC
mechanical strain
microcontact printing
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2022.873531/full

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https://www.frontiersin.org/articles/10.3389/fbioe.2022.873531/full

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