Microphthalmia-Associated Transcription Factor: A Differentiation Marker in Uveal Melanoma

Microphthalmia-Associated Transcription Factor: A Differentiation Marker in Uveal Melanoma

Microphthalmia-associated transcription factor (MITF) is an important regulator of melanogenesis and melanocyte development. In cutaneous melanoma, MITF loss has been linked to an increased expression of stem cell markers, a shift in epithelial-to-mesenchymal transition (EMT)-related factors, and in...

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Bibliographic Details
Main Authors: Maria Chiara Gelmi, Robert M. Verdijk, Laurien E. Houtzagers, Pieter A. van der Velden, Wilma G. M. Kroes, Gregorius P. M. Luyten, T. H. Khanh Vu, Martine J. Jager
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:International Journal of Molecular Sciences
Subjects:
uveal melanoma
pigmentation
MITF (Microphthalmia-associated transcription factor)
prognosis
chromosome status
Online Access:https://www.mdpi.com/1422-0067/24/10/8861

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https://www.mdpi.com/1422-0067/24/10/8861

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