HIF-1α increases the osteogenic capacity of ADSCs by coupling angiogenesis and osteogenesis via the HIF-1α/VEGF/AKT/mTOR signaling pathway

HIF-1α increases the osteogenic capacity of ADSCs by coupling angiogenesis and osteogenesis via the HIF-1α/VEGF/AKT/mTOR signaling pathway

Abstract Background Stabilization and increased activity of hypoxia-inducible factor 1-α (HIF-1α) can directly increase cancellous bone formation and play an essential role in bone modeling and remodeling. However, whether an increased HIF-1α expression in adipose-derived stem cells (ADSCs) increase...

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Bibliographic Details
Main Authors: Shuang Song, Guanhua Zhang, Xutao Chen, Jian Zheng, Xiangdong Liu, Yiqing Wang, Zijun Chen, Yuxi Wang, Yingliang Song, Qin Zhou
Format: Article
Language:English
Published: BMC 2023-08-01
Series:Journal of Nanobiotechnology
Subjects:
Hypoxia-inducible factor 1α
Adipose-derived stem cells
Osteointegration
Osteogenic differentiation
Stem cell transplantation
HIF-1α/VEGF/AKT/mTOR signaling pathway
Online Access:https://doi.org/10.1186/s12951-023-02020-z

Internet

https://doi.org/10.1186/s12951-023-02020-z

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