Discovery and Application of Postnatal Nucleus Pulposus Progenitors Essential for Intervertebral Disc Homeostasis and Degeneration

Discovery and Application of Postnatal Nucleus Pulposus Progenitors Essential for Intervertebral Disc Homeostasis and Degeneration

Abstract Intervertebral disc degeneration (IDD) results from the dysfunction of nucleus pulposus (NP) cells and the exhaustion of NP progenitors (ProNPs). The cellular applications of NP cells during IDD are currently limited due to the lack of in vivo studies showing whether NP cells are heterogene...

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Bibliographic Details
Main Authors: Bo Gao, Bo Jiang, Wenhui Xing, Zaiqi Xie, Zhuojing Luo, Weiguo Zou
Format: Article
Language:English
Published: Wiley 2022-05-01
Series:Advanced Science
Subjects:
intervertebral disc
lineage tracing
nucleus pulposus cell atlas
Sc‐RNA seq
stem cell therapy
Online Access:https://doi.org/10.1002/advs.202104888

Internet

https://doi.org/10.1002/advs.202104888

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