The preparative synthetic approach to 4-(trifluoromethoxy)piperidine and 4-(trifluoromethoxymethyl)piperidine

The preparative synthetic approach to 4-(trifluoromethoxy)piperidine and 4-(trifluoromethoxymethyl)piperidine

Aim. To develop a convenient synthetic approach for the preparation of multigram amounts of 4-(trifluoromethoxy)-piperidine and 4-(trifluoromethoxymethyl)piperidine – promising building blocks for medicinal chemistry. Results and discussion. 4-(Trifluoromethoxy)piperidine (8.4 g) and 4-(trifluoromethox...

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Bibliographic Details
Main Authors: Ivan G. Logvinenko, Violetta G. Dolovanyuk, Ivan S. Kondratov
Format: Article
Language:English
Published: National University of Pharmacy (Kharkiv) 2021-03-01
Series:Журнал органічної та фармацевтичної хімії
Subjects:
fluorination
trifluoromethoxy group
xanthate
piperidine
protection group
Online Access:http://ophcj.nuph.edu.ua/article/view/222669

Internet

http://ophcj.nuph.edu.ua/article/view/222669

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